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Index > Protein center > Tcf4(Gene name) > Mouse
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  • Tcf4 (Gene name),
  • Transcription factor 4 (Protein name ),  ITF2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Tcf4(Itf2;Sef2);
    Protein name:
    Transcription factor 4(TCF-4);
    Alternative:
    Immunoglobulin transcription factor 2(ITF-2;MITF-2);Class A helix-loop-helix transcription factor ME2;SL3-3 enhancer factor 2(SEF-2);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Efficient DNA binding requires dimerization with another bHLH protein. Isoform 2 seems to form inactive heterodimers with MYOD1. Interacts with HIVEP2. Interacts with NEUROD2.
    Function:
    Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Isoform 2 inhibits MYOD1 activation of the cardiac alpha-actin promoter. Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription. May have a regulatory function in developmental processes as well as during neuronal plasticity.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    670
    Sequence:
    50:
    MHHQQRMAAL | GTDKELSDLL | DFSAMFSPPV | SSGKNGPTSL | ASGHFTGSNV | 
    100:
    EDRSSSGSWG | TGGHPSPSRN | YGDGTPYDHM | TSRDLGSHDN | LSPPFVNSRI | 
    150:
    QSKTERGSYS | SYGRENVQGC | HQQSLLGGDM | DMGNPGTLSP | TKPGSQYYQY | 
    200:
    SSNNARRRPL | HSSAMEVQTK | KVRKVPPGLP | SSVYAPSAST | ADYNRDSPGY | 
    250:
    PSSKPAASTF | PSSFFMQDGH | HSSDPWSSSS | GMNQPGYGGM | LGNSSHIPQS | 
    300:
    SSYCSLHPHE | RLSYPSHSSA | DINSSLPPMS | TFHRSGTNHY | STSSCTPPAN | 
    350:
    GTDSIMANRG | TGAAGSSQTG | DALGKALASI | YSPDHTNNSF | SSNPSTPVGS | 
    400:
    PPSLSAGTAV | WSRNGGQASS | SPNYEGPLHS | LQSRIEDRLE | RLDDAIHVLR | 
    450:
    NHAVGPSTAV | PGGHGDMHGI | MGPSHNGAMG | SLGSGYGTSL | LSANRHSLMV | 
    500:
    GAHREDGVAL | RGSHSLLPNQ | VPVPQLPVQS | ATSPDLNPPQ | DPYRGMPPGL | 
    550:
    QGQSVSSGSS | EIKSDDEGDE | NLQDTKSSED | KKLDDDKKDI | KSITRSRSSN | 
    600:
    NDDEDLTPEQ | KAEREKERRM | ANNARERLRV | RDINEAFKEL | GRMVQLHLKS | 
    650:
    DKPQTKLLIL | HQAVAVILSL | EQQVRERNLN | PKAACLKRRE | EEKVSSEPPP | 
    670:
    LSLAGPHPGM | GDAANHMGQM | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    SMR:
    UniGene:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse TCF-4
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    E1408h
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    96T
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    ELISA Kit for Mouse TCF-4
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    ELISA Kit for Mouse TCF-4
    Cat.:
    E1408d
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    Packing:
    96T
    ELISA Kit for Mouse TCF-4
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    E1408m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse TCF-4
    Cat.:
    E1408r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse TCF-4
    Cat.:
    U1408h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse TCF-4
    Cat.:
    U1408r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse TCF-4
    Cat.:
    U1408d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse TCF-4
    Cat.:
    U1408m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse TCF-4
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Mouse TCF-4
    Cat.:
    P1408Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse TCF-4
    Cat.:
    P1408Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse TCF-4
    Polyclonal Antibody for Mouse TCF-4
    Polyclonal Antibody for Mouse TCF-4
    Cat.:
    P1408Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse TCF-4
    Monoclonal Antibody for Mouse TCF-4
    Monoclonal Antibody for Mouse TCF-4
    Monoclonal Antibody for Mouse TCF-4
    Monoclonal Antibody for Mouse TCF-4
    Protein for Mouse TCF-4
    Protein for Mouse TCF-4
    Protein for Mouse TCF-4
    Protein for Mouse TCF-4
    Protein for Mouse TCF-4

    R&D Technical Data
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    Precision
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    Linearity
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    References
    1. 1.
      "Expression of basic-helix-loop-helix transcription factor ME2 during brain development and in the regions of neuronal plasticity in the adult brain."
      Soosaar A. , Chiaramello A. , Zuber M.X. , Neuman T.
      Brain Res. Mol. Brain Res.25:176-180(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Brain.
    2. 2.
      "A splice variant of the ITF-2 transcript encodes a transcription factor that inhibits MyoD activity."
      Skerjanc I.S. , Truong J. , Filion P. , McBurney M.W.
      J. Biol. Chem.271:3555-3561(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3)
    3. 3.
      "The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene."
      Pscherer A. , Doerflinger U. , Kirfel J. , Gawlas K. , Rueschoff J. , Buettner R. , Schuele R.
      EMBO J.15:6680-6690(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      strain: BALB/c.
      tissue: Brain.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      strain: C57BL/6J.
      tissue: Head.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      strain: C57BL/6.
      tissue: Brain.
    6. 6.
      "Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain."
      Doerflinger U. , Pscherer A. , Moser M. , Ruemmele P. , Schuele R. , Buettner R.
      Mol. Cell. Biol.19:3736-3747(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIVEP2
      tissue: Brain.
    7. 7.
      "E protein dosage influences brain development more than family member identity."
      Ravanpay A.C. , Olson J.M.
      J. Neurosci. Res.86:1472-1481(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NEUROD2;DNA-BINDING
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